Tocris Bioscience™ STING Degrader SP23

Product Code. 30000414

Brand: Tocris Bioscience™ 8053/5

Description

Selective STING Degrader (PROTAC™)

STING Degrader SP23 is a selective stimulator of interferon gene (STING) Degrader (PROTAC™; DC50 = 3.2 μM). Comprises the STING inhibitor (C-170), joined by a linker to a CRBN ligand Pomalidomide (Cat. No. 6302). It does not degrade JAK2, STAT3, PI3K, AKT and TLR4 in THP-1 cells. STING Degrader SP23 dose dependently reduces the levels of IFN-β, IL-6, and CXCL10 triggered by cGAMP in THP-1 cells; it also modulates the downstream signals of the STING signaling pathway in vivo. STING Degrader SP23 has high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model.

Negative control STING Degrader N-Me-SP23 (Cat. No. 8054) also available.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

• Chemical Name or Material: (2E)-N1-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
• CAS: 2762552-74-7
• Quantity: 5 mg
• Target: Active Degraders
• Molecular Formula: C₃₄H₃₃N₇O₁₀
• Purity: 98%