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  5. Tocris Bioscience™ STING agonist C53

Tocris Bioscience™ STING agonist C53
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Product Code. 18717306
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18717306

Brand: Tocris Bioscience™ 7741/10

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This item is not returnable. View return policy

Description

Pan-polymorph STING agonist

STING agonist C53 is an activator of human STING (EC50 = 185 nM). It promotes the oligomerization and activation of human STING through a mechanism orthogonal to that of cGAMP. STING agonist C53 increases activity of STING variants in HEK293T cells (107%, 92% and 92% reporter activity against H232, R232 and HAQ, respectively). It induces phosphorylation of STING variants in human tumor cell lines and PBMCs. STING agonist C53 is active at human but not mouse STING. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1 H-indole-6-carboxamide
CAS 2259624-71-8
Quantity 10 mg
Target STING Agonists
Molecular Formula C25H19ClF4N2O2
Purity 0.98
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