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Invitrogen™ STIM2 Polyclonal Antibody

Product Code. 12818562
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12818562 100 μg 100µg
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Product Code. 12818562 Supplier Invitrogen™ Supplier No. PA520373

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Description

Rabbit Polyclonal Antibody

A suggested positive control is A-20 cell lysate. PA5-20373 can be used with blocking peptide PEP-0490.

In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STIM2
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene STIM2
Gene Accession No. P83093, Q9P246
Gene Alias Kiaa1482; OTTHUMP00000123457; OTTHUMP00000123458; OTTHUMP00000216198; Stim2; Stromal interaction molecule 2
Gene Symbols STIM2
Host Species Rabbit
Immunogen A 17 amino acid peptide from near the center of human STIM2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116873, 117087, 57620
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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