missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 18786766

Tocris Bioscience™ StemRegenin 1

Product Code. 18786766
Change view
Click to view available options
Quantity:
10 mg
Unit Size:
10mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
18786766 10 mg 10mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Product Code. 18786766 Supplier Tocris Bioscience™ Supplier No. 7086/10

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment

StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC50 = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells ex vivo. In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9 H-purin-6-yl]amino]ethyl]phenol
CAS 1227633-49-9
Quantity 10 mg
Target Aryl Hydrocarbon Receptor Antagonists
Molecular Formula C24H23N5OS
Purity 0.98
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.