Staurosporine, 99+%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
15495139	Thermo Scientific Alfa Aesar J62837.M¬	1 mg
15485139	Thermo Scientific Alfa Aesar J62837.#0	5 mg
15405149	Thermo Scientific Alfa Aesar J62837.MA	10 mg

Description

Broad spectrum protein kinase inhibitor Staurosporine is used as anti-fungal and anti-hypertensive, which results to study the anti-cancer treatment. It acts as a precursor to protein kinase inhibitor midostaurin. It is also used to induce cell death in Swiss Webster primary macrophage cells and to study the effect of caspase activation on human sperm quality.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Staurosporine is an indolocarbazole alkaloid capable of permeating cell membranes
• Staurosporine has anti-cancer properties that can induce apoptosis
• Staurosporine is a broad inhibitor of protein kinases, preventing growth and division cycles

Application

• Staurosporine is used for research on acute myeloid leukemia
• It is suitable for research applications including cell culture and biochemistry

Chemical Identifiers

• CAS: 62996-74-1
• Molecular Weight (g/mol): 466.541
• InChI Key: HKSZLNNOFSGOKW-ZYSRIHRCSA-N
• PubChem CID: 49831000

• Molecular Formula: C28H26N4O3
• MDL Number: MFCD00077402
• Synonym: Antibiotic AM-2282
• SMILES: CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

Specifications

• Type: Staurosporine
• CAS: 62996-74-1
• Molecular Formula: C28H26N4O3
• Beilstein: 1060573
• Synonym: Antibiotic AM-2282
• InChI Key: HKSZLNNOFSGOKW-ZYSRIHRCSA-N
• Molecular Weight (g/mol): 466.541
• Formula Weight: 466.54
• Color: Yellow

• Physical Form: Powder
• Melting Point: 240°C to 243°C
• MDL Number: MFCD00077402
• Merck Index: 14,8802
• Solubility Information: Soluble in DMSO or ethanol;Soluble in dimethyl sulfoxide ,dimethyl formamide,ethyl acetate,hot acetone and ethanol; Slightly soluble in chloroform and methanol; Insoluble in water.
• SMILES: CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
• PubChem CID: 49831000
• Percent Purity: ≥99%
• Chemical Name or Material: Staurosporine

Safety and Handling

GHS H Statement
H350
May cause cancer.

P201-P202-P280-P308+P313-P501c

H351

missing translation for 'rtecsNumber' : KD5084000

missing translation for 'tsca' : No

missing translation for 'storageNote' : -30° to -10°C

Recommended Storage : Store at -20°C

RUO – Research Use Only