Stat6 (pY641) Mouse anti-Human, Alexa Fluor 647, Clone: 18/P-STAT6, BD

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
15876239	BD Biosciences 612601	50 Tests
15821629	BD Biosciences 562079	250 Tests

Description

Interleukin-4 (IL-4), a major immunoregulatory cytokine, is secreted by activated T lymphocytes, basophils, and mast cells and plays an important role in modulating T helper cell lineage development. It induces specific gene expression via the tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). Stat6, a member of the s ignal t ransducers and a ctivators of t ranscription protein family, mediates signals for IL-4 and, possibly, IL-13. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. Following cytokine receptor ligation, Jak kinases are activated and phosphorylate the cytoplasmic tails of the oligomerized receptors. The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. Thus, Stat6 mediates the IL-4 signal and is essential for the proper development of adaptive immunity.

Specifications

• Antigen: Stat6 (pY641)
• Applications: Flow Cytometry
• Conjugate: Alexa Fluor 647
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Isotype: IgG2a
• Purification Method: Affinity Purified
• Description: Signal transducer and activator of transcription 6; IL-4 Stat

• Clone: 18/P-STAT6
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Immunogen: Phosphorylated Human Stat6 (pY641)
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.