Invitrogen™ STAC2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5140196

Product Code. 17874710

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: KPVRLHSFQE HVFKRASPCE LCHQLIVGNS KQGLRCKMCK VSVHLWCSEE ISHQQCPGKT STSFRRNFSS PLLVHEP Highest antigen sequence indentity to the following orthologs: Rat - 99%, Mouse - 97%.

STAC2 (SH3 and cysteine-rich domain-containing protein 2), also known as 24b2/STAC2, is a 411 amino acid protein that contains one SH3 domain and one phorbol-ester/DAG-type zinc finger. Encoding two alternatively spliced isoforms, the STAC2 gene contains over 15 thousand bases and maps to human chromosome 17q12. Human chromosome 17 comprises over 2.5% of the human genome and encodes over 1, 200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Specifications

• Antigen: STAC2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STAC2
• Gene Alias: 24b2; 24b2/STAC2; AW240854; SH3 and cysteine rich domain 2; SH3 and cysteine-rich domain-containing protein 2; Src homology 3 and cysteine-rich domain-containing protein 2; Stac2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 342667
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6ZMT1
• Gene Symbols: STAC2
• Immunogen: Recombinant protein corresponding to Human STAC2. Recombinant protein control fragment (Product #RP-109600).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG