Invitrogen™ SSTR3 Recombinant Rabbit Monoclonal Antibody (JE63-87)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA544784

Product Code. 17828052

Description

SSTR3 Recombinant Monoclonal Antibody for Western Blot, IHC (P)

Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: SSTR3
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P32745
• Gene Symbols: Sstr3
• Immunogen: Synthetic peptide within human SSTR3 aa 369-418/418.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: JE63-87
• Conjugate: Unconjugated
• Gene: Sstr3
• Gene Alias: Smstr28; Smstr3; Smstr-3; somatostatin receptor; somatostatin receptor 28; somatostatin receptor 3; somatostatin receptor subtype 3; somatostatin receptor type 3; SS3R; SS-3-R; SS3-R; SSR-28; sst3; SSTR; SSTR3
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 6753
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid