SSR 146977 hydrochloride, Tocris Bioscience™

Description

Potent and selective NK3 antagonist

Potent and selective NK3 receptor antagonist (Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively). Also inhibits senktide -induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM).

Specifications

Chemical Identifiers

• CAS: 264618-38-4
• Molecular Formula: C35H43Cl3N4O2
• Molecular Weight (g/mol): 658.105
• InChI Key: HYPKKQPFHSNZBY-GXUZKUJRSA-N
• Synonym: ssr 146977 hydrochloride, ssr 146977 hydrochloride/ssr-146977, n1-1-3-3r-1-benzoyl-3-3-3,4-dichlorophenyl-3-piperidinyl propyl-4-phenyl-piperidinyl-n,n-dimethylurea hydrochloride
• PubChem CID: 90488827
• IUPAC Name: 3-[1-[3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-phenylpiperidin-4-yl]-1,1-dimethylurea;hydrochloride
• SMILES: CN(C)C(=O)NC1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5.Cl

• Quantity: 50 mg
• Formula Weight: 658.11
• Percent Purity: >98%
• Chemical Name or Material: SSR 146977 hydrochloride