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SSEA4 Monoclonal Antibody (eBioMC-813-70 (MC-813-70)), Biotin, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen 13-8843-82

Product Code. 15330080

  • £220.00 / 100µg

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Description

Description

Description: The eBioMC-813-70 monoclonal antibody reacts with a glycolipid carbohydrate epitope on Stage-specific embryonic antigen-4 (SSEA-4) protein. Expression is found on human teratocarcinoma stem cells (EC), human embryonic germ cells (EG), human induced pluripotent stem (iPS) cells, and human embryonic stem cells (ES) with a decrease in expression upon differentiation. Recently expression has also been found on bone marrow mesenchymal stem cells. The eBioMC-813-70 antibody has been reported to crossreact to mouse, rabbit, canine, chicken, and Old and New World monkeys. Applications Reported: This eBioMC-813-70 (MC-813-70) antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBioMC-813-70 (MC-813-70) antibody has been tested by flow cytometric analysis of the 2102Ep cell line. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

SSEA-4 (Stage-specific embryonic antigen 4) is a cell surface antigen, expressed along with SSEA-3, TRA-1-60 and TRA-1-81 in embryonic stem cells, embryonal carcinoma cells and induced pluripotent stem cells (iPS). In human cells, these surface markers are down-regulated during the differentiation process, while SSEA-1 is absent in undifferentiated human stem cells and upregulated on the cell surface after retinoic acid mediated differentiation. Conversely, in mouse stem cells, SSEA-1 expression decreases with differentiation while SSEA-3 and SSEA-4 expression increase.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SSEA4
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Mouse
100 μg
Primary
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
eBioMC-813-70 (MC-813-70)
Biotin
SSEA-4; stage-specific embryonic antigen 4
Affinity chromatography
RUO
Canine, Chicken, Human, Mouse, Non-human Primate, Rabbit
Antibody
IgG3
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