SR 95531 hydrobromide, Tocris Bioscience™

Description

Competitive and selective GABAA antagonist

SR 95531 hydrobromide is a selective, competitive GABAA receptor antagonist and allosteric inhibitor (IC50 = 200 nM). SR 95531 displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Unlike Bicuculline (Cat. No. 0130), SR 95531 selectively antagonizes GABA-induced Cl- currents with little action on Pentobarbitone -induced currents (Cat. No. 4579). SR 95531 can act as an agonist at high concentrations (>100 μM) and is a weak agonist at GABAA receptors with α1β2(Y157S)γ2L subunits. SR 95531 also acts as a competitive antagonist of recombinant glycine receptors and exhibits greater potency at glycine receptors containing β subunits.

Specifications

Chemical Identifiers

• CAS: 104104-50-9
• Molecular Formula: C15H18BrN3O3
• Molecular Weight (g/mol): 368.231
• InChI Key: GFZHNFOGCMEYTA-UHFFFAOYSA-N
• Synonym: gabazine, sr 95531 hydrobromide, gabazine hydrobromide,sr-95531, 1 6h-pyridazinebutanoic acid, 6-imino-3-4-methoxyphenyl-, monohydrobromide, 4-6-imino-3-4-methoxyphenyl pyridazin-1 6h-yl butanoic acid hydrobromide, 6-amino-5-methyl-3-4-methoxyphenyl-1-pyridaziniumbutyric acid br, 6-imino-3-4-methoxyphenyl-1 6h-pyridazinebutanoic acid hydrobromide, 6-imino-3-4-methoxyphenyl-1 6h-pyridazinebutanoic acid monohydrobromide, 1 6h-pyridazinebutanoicacid, 6-imino-3-4-methoxyphenyl-, hydrobromide 1:1, gabazine hydrobromide
• PubChem CID: 107895
• IUPAC Name: 4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;hydrobromide
• SMILES: COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O.Br

• Quantity: 10 mg
• Formula Weight: 368.23
• Percent Purity: >98%
• Chemical Name or Material: SR 95531 hydrobromide