Invitrogen™ SQLE Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5104313

Product Code. 16640765

Description

Antibody detects endogenous levels of total SQLE.

SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family. It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting). It is also post translationally regulated by cholesterol-dependent proteasomal degradation. The MW of SQLE is about 64 kDa.

Specifications

• Antigen: SQLE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SQLE
• Gene Alias: AI323792; Erg1; FLJ30795; SE; Sqle; Squalene epoxidase; squalene monooxygenase; Squalene monooxygenase-like protein
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20775, 29230, 6713
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P52019, P52020, Q14534
• Gene Symbols: SQLE
• Immunogen: A synthesized peptide derived from human SQLE(Accession Q14534), corresponding to amino acid residues W456-V506.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG