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Invitrogen™ SPRYD2 Polyclonal Antibody

Product Code. 12859312
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Quantity:
100 μg
Unit Size:
100µg
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12859312 100 μg 100µg
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Product Code. 12859312 Supplier Invitrogen™ Supplier No. PA521170

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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse heart tissue lysate. PA5-21170 can be used with blocking peptide PEP-1284.

SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPRYD2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CMYA5
Gene Accession No. Q70KF4, Q8N3K9
Gene Alias 2310076E16Rik; 2310076E21Rik; AA420382; AI504003; C5orf10; cardiomyopathy associated 5; cardiomyopathy-associated protein 5; CMYA5; DTNBP2; Dystrobrevin-binding protein 2; genethonin-3; heart and skeletal muscle-specific and sprouty domain-containing; myospryn; SPRY domain-containing protein 2; SPRYD2; sr553; Srfsd; stretch response protein 553; stretch-response protein 553; stretch-responsive fibronectin protein type 3; Tims; TRIM76; TRIM-like protein; tripartite motif-containing 76; tripartite motif-containing protein 76
Gene Symbols CMYA5
Host Species Rabbit
Immunogen An 18 amino acid peptide near the carboxy terminus of human SPRYD2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 202333, 688915, 76469
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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