Invitrogen™ SPOCK2 Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA548009

Product Code. 15538502

Description

This antibody detects human, mouse, and rat Testican 2/SPOCK2 in direct ELISAs and human Testican 2/SPOCK2 in Western blots. Reconstitute at 0.2 mg/mL in sterile PBS.

The SPOCK2 gene encodes the protein testican-2, a member of the SPARC (secreted protein acidic and rich in cysteine) family of extracellular matrix (ECM) proteins. SPOCK2 is involved in modulating the ECM environment, influencing cell-matrix interactions, tissue remodeling, and cellular communication. It plays a role in the regulation of proteolytic activity by inhibiting metalloproteinases, thereby contributing to the maintenance and integrity of the ECM. SPOCK2 is prominently expressed in the brain and testes, highlighting its involvement in neural development and reproductive biology. In neural tissues, it influences processes such as neuronal differentiation, synaptogenesis, and axonal guidance, which are critical for proper brain development and function. Dysregulation of SPOCK2 expression is associated with pathological conditions, including cancer, where it may impact tumor progression and metastasis through alterations in cell adhesion and migration. Research into SPOCK2's specific interactions and mechanisms continues, providing insights into its potential as a therapeutic target for managing ECM-related disorders and diseases involving abnormal cell-matrix interactions.

Specifications

• Antigen: SPOCK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPOCK2
• Gene Alias: AA407235; FLJ97039; Gcap26; granule cell antiserum positive 26; KIAA0275; KIAA0275CWCV; mKIAA0275; sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2; SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2; Spock2; Testican-2; TICN2; UNQ269/PRO306
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361840, 94214, 9806
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunoprecipitation, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q92563, Q9ER58
• Gene Symbols: SPOCK2
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Testican 2/SPOCK2 Glu23-Trp424.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG