Invitrogen™ SPO11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA530549

Product Code. 13435047

Description

Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7. Predicted reactivity: Mouse (83%), Rat (85%), Pig (91%), Bovine (90%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.

Specifications

• Antigen: SPO11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPO11
• Gene Alias: AI449549; Cancer/testis antigen 35; CT35; hypothetical protein LOC402982; meiotic recombination protein SPO11; MGC39953; SPATA43; spermatogenesis associated 43; SPO11; SPO11 initiator of meiotic double stranded breaks; SPO11 meiotic protein covalently bound to DSB; SPO11 meiotic protein covalently bound to DSB homolog; SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae); SPO11, initiator of meiotic double stranded breaks; sporulation protein, meiosis-specific, SPO11 homolog; sporulation protein, meiosis-specific, SPO11 homolog (S. cervisiae); TOPVIA; zgc:77876
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23626
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9Y5K1
• Gene Symbols: SPO11
• Immunogen: Recombinant protein encompassing a sequence within the center region of human SPO11. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG