Invitrogen™ SPAG8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA597169

Product Code. 16550002

Description

Immunogen sequence: LVADRVPNYT SWSQHCPWEP QKQPPWEFLQ VLEPGARGLW KPPDIKGKLM VCYETLPRGQ CLLYNWEEER ATNHLDQVPS MQDGSESFFF RHGHRGLLTM QLKSPMPSST TQKDSYQPPG NVYWPLRGKR EAMLEMLLQH QICKEVQAEQ EPTRKLFEVE SVTHHDYRME LAQAGTPAPT KPHDYRQEQP ETFWIQRAPQ L; Positive Samples: Mouse testis, Rat testis; Cellular Location: Cytoplasmic vesicle, acrosome, secretory vesicle.

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Specifications

• Antigen: SPAG8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPAG8
• Gene Alias: BS-84; CILD28; CT142; HSD-1; hSMP-1; MH-SPAG8; SMP1; SMP-1; SPAG3; Spag8; sperm associated antigen 8; sperm associated antigen 8-like protein; sperm membrane protein 1; Sperm membrane protein BS-84; sperm-associated antigen 8; testicular tissue protein Li 177
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 362508, 433700
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.27 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q3V0Q6
• Gene Symbols: SPAG8
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 220-420 of human SPAG8 (NP_7585161).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG