SP110 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA520460

Product Code. 12828642

Description

A suggested positive control is Hela cell lysate. PA5-20460 can be used with blocking peptide PEP-0577.

Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.

Specifications

• Antigen: SP110
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SP110
• Gene Alias: 5031415C07Rik; 52kDa; 5830484A20Rik; ENSMUSG00000075603; IFI41; Ifi75; interferon-induced protein 41, 30kD; interferon-induced protein 41/75; interferon-induced protein 75, 52kD; intracellular pathogen resistance 1; intracellular pathogen resistance protein 1; Ipr1; phosphoprotein 41; phosphoprotein 75; SP110; Sp110 nuclear body protein; speckled 110 kDa; Transcriptional coactivator Sp110; VODI
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 109032, 301570, 3431
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q3KRF1, Q8BVK9, Q9HB58
• Gene Symbols: SP110
• Immunogen: A 15 amino acid peptide near the carboxy terminus of the human IPR1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG