Invitrogen™ Sortilin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA596865

Product Code. 16539701

Description

Positive Samples: A-549, Jurkat; Cellular Location: Cell membrane, Endoplasmic reticulum membrane, Endosome membrane, Extracellular side, Golgi apparatus, Golgi stack membrane, Lysosome membrane, Membrane, Nucleus membrane, Single-pass type I membrane protein Immunogen sequence: GRFLVHRYSV LQQHAEANGV DGVDALDTAS HTNKSGYHD.

Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.

Specifications

• Antigen: Sortilin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Sort1
• Gene Alias: 100 kDa NT receptor; 2900053A11Rik; AI852375; Glycoprotein 110; glycoprotein 95; Gp110; Gp95; LDLCQ6; mNTR3; neurotensin receptor 3; NT3; NTR3; Nts3; Ntsr3; Sort1; Sortilin; sortilin 1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20661, 6272, 83576
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.59 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O54861, Q6PHU5, Q99523
• Gene Symbols: Sort1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 785-823 of human SORT1 (NP_0029503).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG