Invitrogen™ Sonepcizumab Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30284017	Invitrogen™ MA559795	100 μg
30284328	Invitrogen™ MA559796	1 mg

Description

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

Sonepcizumab, also referred to as LT1009, is a humanized monoclonal antibody that targets sphingosine 1-phosphate (S1P), a signaling lipid active in promoting angiogenesis and tumor growth. Sphingosine-1-phosphate (S1P) is a critical lysolipid involved in multiple biological functions, including heart development, immune response, and hearing. It is a metabolite from cell membrane sphingolipids and is primarily regulated through its binding to specific G protein-coupled receptors named S1P receptors (S1PRs). These receptors are ubiquitously expressed in the human body, influencing various physiological and pathological processes. The signaling pathways initiated by S1P-S1PR interactions are crucial for immune cell trafficking, activation, and adaptive immune responses. Studies also highlight the role of S1P in regulating vascular stability, endothelial cell function, and as a mediator in inflammatory responses. The SPNS2 gene encodes a transporter protein essential for the active secretion of S1P, further emphasizing its relevance in maintaining physiological homeostasis.

Specifications

• Antigen: Sonepcizumab Humanized
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Lyophilized
• Isotype: IgG1
• Target Species: Human
• Primary or Secondary: Primary
• Purification Method: Protein A

• Concentration: 1 mg/mL
• Applications: ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
• Conjugate: Unconjugated
• Host Species: Human
• Regulatory Status: RUO
• Formulation: 25 mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
• Product Type: Antibody