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STEMCELL Technologies Soluble ICAM-1/CD54, Mouse, Recombinant

Product Code. 17138051
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. 17138051

Brand: STEMCELL Technologies 02203

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Description

Soluble ICAM-1 (CD54)

  • Mouse soluble ICAM-1 (∼95kDa) is a recombinant protein derived from the cell adhesion molecule
  • This membrane protein is expressed on many cell types and is upregulated upon cell activation
  • It binds to LFA-1 and Mac-1 on leukocytes
  • Cell adhesion mediated by these molecules is critical for a wide range of cellular interactions in the immune system, including leukocyte adhesion to endothelial cells and interaction between T cells and antigen-presenting cells
  • The adhesion of leukocytes to ICAM-1 requires functional activation of LFA-1 or Mac-1 on leukocytes
  • Purified sICAM-1 adsorbed to a solid support binds activated cells expressing LFA-1 or Mac-1
  • This binding can be blocked by the monoclonal anti-ICAM-1 antibody (in mouse with clone YN1/1; Catalog #01503), anti-LFA-1 or anti-Mac-1, indicating a direct interaction of these molecules in cell adhesion
  • Soluble ICAM is useful for the studies of the activation of leukocyte adhesion in immune responses and inflammatory reactions

Specifications

Quantity 100 μg
Cell Type Lymphocytes; T Cells
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