Sodium Channel Pan Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA577723

Product Code. 15964225

Description

Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 μL of deionized water.

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Specifications

• Antigen: Sodium Channel Pan
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SCN1A
• Gene Alias: SP-19
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 24766, 29701, 29710, 497770, 110880, 11280, 20273, 25722, 6323, 6328, 6329, 6336, 20271, 20274, 25665, 29571, 20265, 20269, 24046, 6326, 6331, 6334, 6335, 78956, 81574, 110876, 20264
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: A2APX8, Q9NY46, P04774, P35498, P35499, Q14524, Q9WTU3, Q9Y5Y9, O08562, Q62205, Q62968, Q15858, Q6QIY3, Q99250, Q9ER60, Q9R053, O88420, O88457, P04775, P15390, Q9JJV9, Q9UQD0, P08104, P15389, Q9UI33
• Gene Symbols: Scn10a, Scn11a, Scn1a, Scn2a, Scn3a, Scn4a, Scn5a, Scn8a, Scn9a
• Immunogen: Peptide TEEQKKYYNAMKKLGSKK(C), corresponding to amino acid residues 1501-1518 of rat Nav 1.1
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG