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Invitrogen™ SnoN Polyclonal Antibody

Product Code. 12858442
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12858442 100 μg 100µg
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Product Code. 12858442 Supplier Invitrogen™ Supplier No. PA520306

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Description

Rabbit Polyclonal Antibody

A suggested positive control is A431 cell lysate. PA5-20306 can be used with blocking peptide PEP-0400.

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SnoN
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SKIL
Gene Accession No. P12757, Q60665
Gene Alias EGK_11909; LOW QUALITY PROTEIN: ski-like protein; SKI like proto-oncogene; ski/sno related; SKIL; SKI-like; SKI-like oncogene; ski-like protein; ski-like protein-like; SKI-like proto-oncogene; Skir; ski-related oncogene; ski-related oncogene snoN; Ski-related protein; SNO; SnoA; SnoI; SnoN; v-ski sarcoma viral oncogene homolog
Gene Symbols SKIL
Host Species Rabbit
Immunogen A 16 amino acid peptide from near the amino terminus of human SnoN.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114208, 20482, 6498
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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