Invitrogen™ SNAP23 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA531028

Product Code. 13455537

Description

Recommended positive controls: A431, Raji, mouse brain, rat brain. Predicted reactivity: Mouse (85%), Rat (85%), Pig (87%), Rabbit (88%), Rhesus Monkey (97%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

Specifications

• Antigen: SNAP23
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SNAP23
• Gene Alias: 23kDa; AA408749; HsT17016; OTTHUMP00000161263; SNAP23; SNAP-23; SNAP23A; SNAP23B; Sndt; Synaptosomal-associated protein 23; synaptosomal-associated protein 23 kD; synaptosomal-associated protein, 23 kD; synaptosomal-associated protein, 23kD; synaptosomal-associated protein, 23kDa; synaptosome associated protein 23; synaptosome associated protein 23kDa; Syndet; Vesicle-membrane fusion protein SNAP-23
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20619, 64630, 8773
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O00161, O09044, O70377
• Gene Symbols: SNAP23
• Immunogen: Recombinant protein encompassing a sequence within the center region of human SNAP23. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG