Snail Mouse anti-Human, Clone: 20C8, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-9859-80
Code : NEW
Additional Details : Weight : 0.09500kg
DescriptionThe monoclonal antibody 20C8 recognizes human Snail1, a 29kDa zinc finger transcription factor. Snail1 and Slug both belong to a family of transcription factors that are responsible for inducing epithelial to mesenchymal transition (EMT) during normal organ development and tumor progression. Snail1 expression is localized to both the cytoplasm and nucleus and functions as a transcriptional repressor of E-cadherin, claudins, occludin, and desmoplakin. During embryonic development, Snail1 is localized to the mesoderm, while in the adult, expression is inducible and is usually limited to activated fibroblasts and some mesenchymal cells. Overexpression of Snail1 has been found in carcinomas and fibrosarcomas and may be used as an early marker for EMT.
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Store at 2-8°C.|