Invitrogen™ SMURF2 Monoclonal Antibody (690638)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA524314

Product Code. 15574002

Description

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

Specifications

• Antigen: SMURF2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: A2A5Z6, Q9HAU4
• Gene Symbols: Smurf2
• Immunogen: E. coli-derived recombinant human SMURF2 Met490-Glu748.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Western Blot
• Clone: 690638
• Conjugate: Unconjugated
• Gene: Smurf2
• Gene Alias: 2810411E22Rik; AI558114; AI649275; E3 ubiquitin ligase SMURF2; E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; hSMURF2; RGD1310067; SMAD specific E3 ubiquitin protein ligase 2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; SMURF2
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 303614, 64750, 66313
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized