Invitrogen™ SMURF2 Monoclonal Antibody (1826CT865.51.28)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA537753

Product Code. 17177338

Description

SMURF2 Monoclonal Antibody for Western Blot

SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

Specifications

• Antigen: SMURF2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: Smurf2
• Gene Alias: 2810411E22Rik; AI558114; AI649275; E3 ubiquitin ligase SMURF2; E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; hSMURF2; RGD1310067; SMAD specific E3 ubiquitin protein ligase 2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; SMURF2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 64750
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Clone: 1826CT865.51.28
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q9HAU4
• Gene Symbols: Smurf2
• Immunogen: recombinant protein of human SMURF2.
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ