Invitrogen™ SMO Recombinant Rabbit Monoclonal Antibody (HL2975)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA556875

Product Code. 30275544

Description

SMO Recombinant Monoclonal Antibody for Western Blot

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.

Specifications

• Antigen: SMO
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P56726, Q99835
• Gene Symbols: SMO
• Immunogen: Recombinant fragment encompassing a sequence within the Intracellular domain of human Smoothened homolog. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Clone: HL2975
• Conjugate: Unconjugated
• Gene: SMO
• Gene Alias: bent body; bnb; E130215L21Rik; frizzled family member 11; FZD11; Gx; HGNC:11119; Protein Gx; Protein SMOH; seven transmembrane helix receptor; SMO; SMOH; smoothened; Smoothened homolog; smoothened homolog (Drosophila); smoothened, frizzled class receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 319757, 6608
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid