Invitrogen™ SMC5 Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA5142480

Product Code. 17897512

Description

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.

Specifications

• Antigen: SMC5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Smc5
• Gene Alias: hSMC5; KIAA0594; mKIAA0594; MLZ-453; mSMC5; Protein expressed in male leptotene and zygotene spermatocytes 453; SMC protein 5; Smc5; SMC-5; SMC5 structural maintenance of chromosomes 5-like 1; Smc5l1; structural maintenance of chromosomes 5; structural maintenance of chromosomes protein 5
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 23137
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8IY18
• Gene Symbols: Smc5
• Immunogen: Peptide with sequence C-TSKHLEHKDNELRQ (aa 679-692).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG