Invitrogen™ SMC1B Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA588855

Product Code. 16566941

Description

Immunogen sequence: ILLKTAAPNL RALENLKTVR DKFQESTDAF EASRKEARLC RQEFEQVKKR RYDLFTQCFE HVSISIDQIY KKLCRNNSAQ VSSYIKEQTQ DQFQMIVISL KEEFYSRADA LIGIYPEYDD CMFSRVLTLD LSQYPDTEGQ ESSKRHGESR; Positive Samples: Rat testis; Cellular Location: Chromosome, Nucleus, centromere.

The SMC1B gene encodes a meiosis-specific subunit of the cohesin complex, which is essential for proper chromosome segregation during meiosis. It plays a critical role in sister chromatid cohesion and DNA recombination. The SMC1B protein, also known as SMC1 beta, forms a heterodimer with SMC3, which is necessary for the formation of the cohesin complex that holds sister chromatids together until anaphase. Studies have demonstrated that SMC1B is required for the activation of the spindle assembly checkpoint (SAC) during oocyte meiosis. The loss of SMC1B function leads to improper chromosome alignment and segregation, resulting in infertility due to meiotic arrest. Furthermore, the gene is expressed exclusively during meiosis, and mutations or deletions within SMC1B can cause sterility due to disruptions in meiotic progression.

Specifications

• Antigen: SMC1B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Smc1b
• Gene Symbols: Smc1b
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1012-1161 of human SMC1B (NP_0012784301).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Concentration: 1.52 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Alias: bK268H5; bK268H5.5; mitosis-specific chromosome segregation protein like protein beta; RP1-102D24.3; SMC; SMC protein 1B; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 2; SMC1B; SMC-1B; SMC1BETA; SMC-1-beta; SMC1L2; structural maintenace of chromosomes 1B; structural maintenance of chromosomes 1B; structural maintenance of chromosomes protein 1B
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 300121
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid