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SMAD1/SMAD9 Polyclonal Antibody, Invitrogen™

Product Code. 16642705
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Quantity:
100 μL
Unit Size:
100µL
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16642705 100 μL 100µL
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Product Code. 16642705 Supplier Invitrogen Supplier No. PA5106266

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Smad1/9.

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMAD1/SMAD9
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SMAD9
Gene Accession No. O15198, O54835, P70340, P97588, Q15797, Q9JIW5
Gene Alias AI528653; BSP1; BSP-1; Dwarfin-A; dwf-A; JV41; JV4-1; MAD (mothers against decapentaplegic, Drosophila) homolog 1; MAD homolog 1; MAD homolog 9; MAD homolog1 (mothers against decapentaplegic, Drosophila); MAD, mothers against decapentaplegic homolog 1; Madh1; MADH6; Madh8; Madh9; MADR1; mad-related protein 1; Mlp1; mMad1; mothers against decapentaplegic homolog 1; Mothers against decapentaplegic homolog 9; Mothers against decapentaplegic, drosophila, homolog of, 9; mothers against DPP homolog 1; mothers against DPP homolog 9; mothers-against-DPP-related 1; MusMLP; PPH2; SMAD; Smad 1; SMAD 9; SMAD family member 1; SMAD family member 9; SMAD, mothers against DPP homolog 1; SMAD, mothers against DPP homolog 9; Smad1; SMAD8; SMAD8/9; SMAD8A; SMAD8B; Smad9; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1
Gene Symbols Smad1, SMAD9
Host Species Rabbit
Immunogen A synthesized peptide derived from human SMAD1(Accession Q15797), corresponding to amino acid residues I436-S465.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17125, 25671, 4086, 4093, 55994, 85435
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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