SMAD1 Mouse anti-Human, Mouse, Rat, Clone: 2D10B8, Proteintech

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
16868545	Proteintech 66559-1-IG-20UL	20 μL
16858545	Proteintech 66559-1-IG-150UL	150 μL

Description

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ′mothers against decapentaplegic′ (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

Specifications

• Antigen: SMAD1
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: BSP 1, BSP1, hSMAD1, JV4 1, JV41, MAD homolog 1, Mad related protein 1, MADH1, MADR1, Mothers against DPP homolog 1, SMAD 1, SMAD family member 1, SMAD1
• Gene Symbols: Smad1
• Isotype: IgG1
• Purification Method: Protein G
• Product Type: Antibody

• Clone: 2D10B8
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Rat, Mouse, Human
• Gene Accession No.: P70340, P97588, Q15797
• Gene ID (Entrez): 17125, 25671, 4086
• Immunogen: SMAD1 Fusion Protein Ag0701
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SMAD1