Invitrogen™ SLUG Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA585522

Product Code. 16372455

Description

Keep as concentrated solution. Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (85%), Xenopus laevis (95%), Dog (100%), Pig (97%), Sheep (98%), Rhesus Monkey (100%), Bovine (99%). Positive Control: human Slug-transfected 293T cells, U87-MG, SK-N-SH, IMR32, SK-N-AS, NT2D1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.

Specifications

• Antigen: SLUG
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SNAI2
• Gene Alias: MGC10182; neural crest transcription factor Slug; Protein snail homolog 2; SLUG; slug (chicken homolog), zinc finger protein; Slug, chicken homolog; Slugh; SLUGH1; Snai2; snail family transcriptional repressor 2; snail family zinc finger 2; snail homolog 2; Snail2; snail-like protein 2; WS2D; Zinc finger protein SNAI2; zinc finger transcription factor snail 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20583, 6591
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.18 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: O43623, P97469
• Gene Symbols: SNAI2
• Immunogen: Recombinant protein encompassing a sequence within the center region of human SLUG. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG