Invitrogen™ SLUG Monoclonal Antibody (2H5)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA515628

Product Code. 11365593

Description

MA5-15628 targets SNAI2 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15628 immunogen is purified recombinant fragment of human SNAI2 expressed in E. Coli. MA5-15628 detects SNAI2 which has a predicted molecular weight of approximately 30kDa.

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.

Specifications

• Antigen: SLUG
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.03% sodium azide
• Gene Accession No.: O43623
• Gene Symbols: SNAI2
• Immunogen: Purified recombinant fragment of human SNAI2 expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 6591
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Western Blot
• Clone: 2H5
• Conjugate: Unconjugated
• Gene: SNAI2
• Gene Alias: MGC10182; neural crest transcription factor Slug; Protein snail homolog 2; SLUG; slug (chicken homolog), zinc finger protein; Slug, chicken homolog; Slugh; SLUGH1; Snai2; snail family transcriptional repressor 2; snail family zinc finger 2; snail homolog 2; Snail2; snail-like protein 2; WS2D; Zinc finger protein SNAI2; zinc finger transcription factor snail 2
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1