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Invitrogen™ SLUG Monoclonal Antibody (2H5)
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Product Code. 11365593
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
11365593 100 μL 100µL
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Product Code. 11365593 Supplier Invitrogen™ Supplier No. MA515628

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Description

Mouse Monoclonal Antibody

MA5-15628 targets SNAI2 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15628 immunogen is purified recombinant fragment of human SNAI2 expressed in E. Coli. MA5-15628 detects SNAI2 which has a predicted molecular weight of approximately 30kDa.

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLUG
Applications ELISA, Western Blot
Classification Monoclonal
Clone 2H5
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene SNAI2
Gene Accession No. O43623
Gene Alias MGC10182; neural crest transcription factor Slug; Protein snail homolog 2; SLUG; slug (chicken homolog), zinc finger protein; Slug, chicken homolog; Slugh; SLUGH1; Snai2; snail family transcriptional repressor 2; snail family zinc finger 2; snail homolog 2; Snail2; snail-like protein 2; WS2D; Zinc finger protein SNAI2; zinc finger transcription factor snail 2
Gene Symbols SNAI2
Host Species Mouse
Immunogen Purified recombinant fragment of human SNAI2 expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6591
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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