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Invitrogen™ SLITRK1 Polyclonal Antibody

Product Code. 12808652
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Quantity:
100 μg
Unit Size:
100µg
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12808652 100 μg 100µg
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Product Code. 12808652 Supplier Invitrogen™ Supplier No. PA520470

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human brain tissue lysate. PA5-20470 can be used with blocking peptide PEP-0590.

SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLITRK1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SLITRK1
Gene Accession No. Q810C1, Q96PX8
Gene Alias 3200001I04Rik; KIAA1910; Leucine-rich repeat-containing protein 12; LRRC12; RP11-395N17.1; SLIT and NTRK like family member 1; SLIT and NTRK-like family, member 1; SLIT and NTRK-like protein 1; slit and trk like gene 1; SLITRK1; Sltk1; TTM; UNQ233/PRO266
Gene Symbols SLITRK1
Host Species Rabbit
Immunogen An 18 amino acid peptide from near the center of human Slitrk1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114798, 306147, 76965
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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