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Invitrogen™ SLFN12 Polyclonal Antibody

Product Code. 12849012
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12849012 100 μg 100µg
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Product Code. 12849012 Supplier Invitrogen™ Supplier No. PA520867

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Description

Rabbit Polyclonal Antibody

A suggested positive control is SK-N-SH cell lysate. PA5-20867 can be used with blocking peptide PEP-0981.

Despite being first described several years ago, the roles of the Schlafen (SLFN) family of proteins remain largely unknown. The SLFN genes are preferentially expressed in lymphoid tissues and differentially regulated during thymocyte maturation. It is thought that many play roles in cell growth, hemopoietic cell differentiation, and T cell development and maturation. Most members contain at least one divergent AAA domain (AAA_4) that may play a role in ATP binding. Although also known as SLFN3, a Schlafen family member that may be a marker of T cell activation, human SLFN12 has relatively low homology to SLFN3 in other species. Loss of the SLFN12 gene due to deletion is associated with Kabuki syndrome, a multiple congenital anomaly syndrome, suggesting SLFN may play a role in this genetic condition.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLFN12
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SLFN12
Gene Accession No. Q8IYM2
Gene Alias Schlafen family member 12; SLFN12; SLFN3
Gene Symbols SLFN12
Host Species Rabbit
Immunogen a 12 amino acid peptide from near the carboxy terminus human SLFN12.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55106
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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