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Invitrogen™ SLC35D1 Polyclonal Antibody

Product Code. 12828732
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Quantity:
100 μg
Unit Size:
100µg
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12828732 100 μg 100µg
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Product Code. 12828732 Supplier Invitrogen™ Supplier No. PA520552

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat liver tissue lysate. PA5-20552 can be used with blocking peptide PEP-0672.

The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC35D1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SLC35D1
Gene Accession No. Q9NTN3
Gene Alias AI834976; C330011J09; KIAA0260; mKIAA0260; SLC35D1; solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1; solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1; solute carrier family 35 member D1; solute carrier family 35, member D1; UDP-galactose transporter-related 7; UDP-galactose transporter-related protein 7; UDP-GlcA/UDP-GalNAc transporter; UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; UGTREL7
Gene Symbols SLC35D1
Host Species Rabbit
Immunogen A 20 amino acid peptide near the carboxy terminus of the human Slc35D1.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23169
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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