Invitrogen™ SLC28A2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA590922

Product Code. 16568051

Description

Immunogen sequence: GAFIAFGVDA SSLISASVMA APCALASSKL AYPEVEESKF KSEEGVKLPR GKERNVLEAA SNGAVDAIGL ATNVAANLIA FLAVLAFINA ALSWLGELVD I; Positive Samples: HepG2, 293T, HT-29, BxPC-3, Mouse heart, Mouse spleen, Rat liver, Rat heart; Cellular Location: Membrane, Multi-pass membrane protein.

The concentrative nucleoside transporter (CNT) family comprises three members: CNT1, CNT2 and CNT3. CNT2 participates in the absorption and disposition of endogenous nucleosides and mediates the first step of nucleotide biosynthesis. CNT2 levels are highly dependent on insulin (but not glucose) concentration, and the protein is under the control of the Adenosine 1 receptor. CNT family members are imperative in the response of cells to a variety of anticancer and antiviral nucleoside analogs, as the CNT proteins modulate their entry into target tissues. Increasing evidence also suggests that CNT2 may have a role in energy metabolism because activation of CNT2 relies on the opening of ATP-sensitive K+ channels.

Specifications

• Antigen: SLC28A2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLC28A2
• Gene Alias: 2010208B10Rik; B430217P18; BB152493; CNT 2; CNT2; CNT-2; Concentrative nucleoside transporter 2; HCNT2; HsT17153; Na(+)/nucleoside cotransporter 2; purine-selective Na+ nucleoside cotransporter; rCNT2; Slc28a2; sodium/nucleoside cotransporter 2; sodium/purine nucleoside cotransporter; Sodium/purine nucleoside co-transporter; Sodium-coupled nucleoside transporter 2; solute carrier family 28 (concentrative nucleoside transporter), member 2; solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; solute carrier family 28 member 2; solute carrier family 28, member 2; SPNT; SPNT1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 269346, 60423, 9153
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O43868, O88627, Q62773
• Gene Symbols: SLC28A2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SLC28A2 (NP_0042032).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG