Invitrogen™ SLC25A13 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA521991

Product Code. 13270029

Descripción

Recommended positive controls: 293T, A431, HeLa, HepG2, mouse liver, rat liver. Predicted reactivity: Mouse (96%), Xenopus laevis (88%), Chicken (94%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2 or CTLN2, is a 675 amino acid multi-pass membrane protein that localizes to the inner membrane of the mitochondrion. Expressed in liver, pancreas, kidney, brain, heart and placenta, citrin functions as a calcium-dependent glutamate and aspartate carrier that is thought to play a role in the urea cycle. Citrin, a member of the mitochondrial carrier family, contains three Solcar repeats and four EF-hand domains through which it binds calcium. Defects in the gene encoding citrin are the cause of citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD). CTLN2 is an autosomal recessive disease that results from errors in the urea cycle and is characterized by neuropsychiatric symptoms such as loss of memory, seizures and coma. NICCD, a non-lethal disorder, occurs during infancy and is characterized by low birth weight, reduced bile flow, growth retardation and hepatic fibrosis.

Especificaciones

• Antigen: SLC25A13
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Slc25a13
• Gene Alias: AI785475; ARALAR2; Calcium-binding mitochondrial carrier protein Aralar2; citrin; CTLN2; Ctrn; Mitochondrial aspartate glutamate carrier 2; RGD1565889; SLC25A13; solute carrier family 25 (aspartate/glutamate carrier), member 13; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13; solute carrier family 25 member 13; solute carrier family 25, member 13; solute carrier family 25, member 13 (citrin)
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10165, 362322, 50799
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.61 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q9QXX4, Q9UJS0
• Gene Symbols: Slc25a13
• Immunogen: Recombinant protein encompassing a sequence within the center region of human SLC25A13. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG