Invitrogen™ SLC22A4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
17743004	Invitrogen™ PA5121606	20 μL
17733004	Invitrogen™ PA5121605	100 μL

Description

Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia.

Specifications

• Antigen: SLC22A4
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q9H015
• Gene ID (Entrez): 6583
• Immunogen: Leu42-Lys141 (Accession Q9H015), with N-terminal His Tag.
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Gene: SLC22A4

• Concentration: 0.5 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Alias: ergothioneine transporter; ET transporter; ETT; integral membrane transport protein; LSTP-Like 2; Octn1; organic cation transporter 1; organic cation transporter OCTN1; organic cation/carnitine transporter 1; SLC22A4; solute carrier family (organic cation transporter), member 4; solute carrier family 22 (organic cation transporter), member 4; solute carrier family 22 (organic cation/ergothioneine transporter), member 4; solute carrier family 22 (organic cation/zwitterion transporter), member 4; solute carrier family 22 member 4; UT2H
• Gene Symbols: SLC22A4
• Isotype: IgG
• Purification Method: Antigen affinity chromatography, Protein A
• Product Type: Antibody