Invitrogen™ SLA Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA522356

Product Code. 13249658

Description

Recommended positive controls: 293T, A431. Predicted reactivity: Mouse (87%), Rat (87%), Bovine (91%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

SLAP also known as Src-like-adapter protein 1 is a 276 amino acid containing adapter protein, functioning as a negative regulator of T-cell receptor (TCR) signaling. SLAP belonging to the SRC family of cytoplasmic tyrosine kinases contains a SH2 domain and a SH3 domain. This cytoplasmic protein colocalizes with endosomes and is known to inhibit T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. It acts as a negative regulator of positive selection and mitosis of T-cells. SLAP may act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Expression of SLAP is weak in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas but is high in lung and fetal brain.

Specifications

• Antigen: SLA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLA
• Gene Alias: hSLAP; Sla; SLA1; SLAP; Slap1; Slap-1; Src like adaptor; src-like adaptor; src-like-adapter; Src-like-adapter protein 1; Src-like-adaptor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20491, 6503
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.87 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q13239, Q60898
• Gene Symbols: SLA
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Slap. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG