Invitrogen™ SKP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA528489

Product Code. 13422607

Description

Recommended positive controls: A549, H1299, HCT116, MCF-7, NIH-3T3. Predicted reactivity: Rat (100%), Zebrafish (99%), Xenopus laevis (100%), Dog (100%), Chicken (100%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%), Guinea pig (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteasome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Specifications

• Antigen: SKP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SKP1
• Gene Alias: 15kDa; 2610043E24Rik; 2610206H23Rik; cyclin A/CDK2-associated p19; cyclin A/CDK2-associated protein p19; cyclin-A/CDK2-associated protein p19; EMC19; MGC34403; OCP2; OCP-2; OCP-II; OCP-II protein; organ of Corti protein 2; Organ of Corti protein II; p19A; p19Skp1; polypeptide 1-like; RNA polymerase II elongation factor-like protein; RNA polymerase II elongation factor-like protein OCP2; SIII; Skp1; Skp1a; S-phase kinase-associated protein 1; S-phase kinase-associated protein 1A; TCEB1L; transcription elongation factor B polypeptide 1-like
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21402, 6500
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P63208, Q9WTX5
• Gene Symbols: SKP1, Skp1a
• Immunogen: Recombinant protein encompassing a sequence within the center region of human SKP1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG