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Invitrogen™ SKAP2 Polyclonal Antibody

Product Code. 13269978
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Quantity:
100 μL
Unit Size:
100µg
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13269978 100 μL 100µg
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Product Code. 13269978 Supplier Invitrogen™ Supplier No. PA521757

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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HepG2. Predicted reactivity: Rhesus Monkey (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SKAP2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 10% glycerol and 0.01% thimerosal; pH 7
Gene SKAP2
Gene Accession No. O75563
Gene Alias 2610021A10Rik; AA960083; BB137539; Fyn-associated phosphoprotein SKAP55 homologue; MGC10411; MGC33304; mSKAP55R; PRAP; pyk2/RAFTK-associated protein; RA70; Retinoic acid-induced protein 70; Saps; SCAP2; Scap55r; Skap2; SKAP55 homolog; SKAP55 homologue; SKAP-55HOM; SKAP55-HOM; SKAP55R; SKAP-HOM; src family associated phosphoprotein 2; src family-associated phosphoprotein 2; src kinase associated phosphoprotein 2; src kinase-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; src kinase-associated phosphoprotein of 55-related protein; src-associated adapter protein with PH and SH3 domains; Src-associated adaptor protein
Gene Symbols SKAP2
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human SCAP2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8935
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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