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Tocris Bioscience™ SJF 1521
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Product Code. 18727366
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Quantity:
5 mg
Unit Size:
5mg
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Product Code. 18727366

Brand: Tocris Bioscience™ 7261/5

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This item is not returnable. View return policy

Description

Selective EGFR PROTAC™

SJF 1521 is a selective EGFR PROTAC™ Degrader. SJF 1521 comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Exhibits selectivity for EGFR, including mutant forms, over HER2. Induces degradation of EGFR in OVCAR8 cells. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (2 S,4 R)-1-(-2-(tert-Butyl)-14-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS 2230821-40-4
Quantity 5 mg
Target Active Degraders
Molecular Formula C57H61ClFN7O9S
Purity 0.98
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