Sitravatinib, MedChemExpress

Product Code. 16489747

Brand: Medchem Express HY16961

Description

MedChemExpress Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

Specifications

• Chemical Name or Material: Sitravatinib
• CAS: 1123837-84-2
• Color: Off-White
• Purity Grade Notes: Research
• Molecular Formula: C₃₃H₂₉F₂N₅O₄S
• Quantity: 5 mg
• Synonym: MGCD516 MG-516
• Solubility Information: DMSO : ≥ 32 mg/mL (50.82 mM)
• SMILES: O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)NC3=CC=C(OC4=C5C(C=C(C6=NC=C(CNCCOC)C=C6)S5)=NC=C4)C(F)=C3
• Molecular Weight (g/mol): 629.68
• Formula Weight: 629.68
• Percent Purity: 98.2%
• Grade: Research
• Physical Form: Solid
• For Use With (Application): Cancer-Kinase/protease

Research purposes only