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Description
SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.
Specifications
Specifications
| Antigen | SIRT5 |
| Applications | Immunofluorescence, Immunocytochemistry, Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Concentration | 0.27 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | SIRT5 |
| Gene Accession No. | Q68FX9, Q8K2C6, Q9NXA8 |
| Gene Alias | SIR2 like protein 5, SIR2L5, SIRT5 |
| Gene Symbols | Sirt5 |
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Product Title
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