SIRT2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA125472

Product Code. 11595653

Description

Recommended positive controls: NIH3T3. Predicted molucular weight of 43 kDa.

The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.

Specifications

• Antigen: SIRT2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIRT2
• Gene Alias: 5730427M03Rik; 5E5 antigen; mSIR2L2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent information regulator 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2; SIR2; SIR2L; SIR2L2; SIR2-like protein 2; sir2-related protein type 2; Sirt2; sirtuin 2; sirtuin type 2; sirtuin-2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22933, 64383
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Concentration: 1.33 mg/mL
• Formulation: 0.01M PBS with 1% BSA and 15mM sodium azide; pH 7.4
• Gene Accession No.: Q8IXJ6, Q8VDQ8
• Gene Symbols: SIRT2
• Immunogen: Synthetic peptide corresponding to the C-terminal residues 722-737 of mouse SIR2/SIRT2, with a C-terminal added lysine.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG