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Invitrogen™ SIRT1 Polyclonal Antibody

Product Code. 12829112
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Quantity:
100 μg
Unit Size:
100µg
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12829112 100 μg 100µg
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Product Code. 12829112 Supplier Invitrogen™ Supplier No. PA520964

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Description

Chicken Polyclonal Antibody

A suggested positive control is mouse liver tissue lysate. PA5-20964 can be used with blocking peptide PEP-1078.

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIRT1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SIRT1
Gene Accession No. A0A0G2JZ79, Q923E4, Q96EB6
Gene Alias 75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2; Sir2a; SIR2alpha; SIR2L1; sir2-like 1; SIR2-like protein 1; SIRT 1; SIRT1; SIRT-1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1
Gene Symbols SIRT1
Host Species Chicken
Immunogen A 19 amino acid peptide near the amino terminus of human SIRT1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23411, 309757, 93759
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgY
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