IgG1-Fc Recombinant Human Protein, Invitrogen™ Sino Biological™

Product Code. 13435946

Brand: Invitrogen 10702HNAH250

Description

This recombinant human protein is expressed from a DNA sequence encoding the human IgG1-Fc region (AAC82527.1), containing residues 99 to 330, including a 103 Cys/Ser mutation

Immunoglobulin gamma-1 heavy chain constant region, partial (IgG1-Fc), recombinant human protein is supplied as a lyophilized powder. In general, recombinant proteins can be used as protein standard and in cell biology research applications.&line-break;Background: Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). Recombinant IgG Fc is suggested to represent a potential anti-inflammatory drug for treatment of human autoimmune diseases.

• N-terminal Sequence Analysis: Glu 99
• Activity: 1. Measured by its ability to bind human CD16a-His (Mfr. No. 10389-H08H1) in a functional ELISA; 2. Measured by its ability to bind human CD16a-AVI-His (Mfr. No. 10389-H27H) in a functional ELISA; 3.Measured by its ability to bind human CD16a-His (Mfr. No. 10389-H08H) in a functional ELISA
• Formulation: lyophilized in PBS, pH 7.4, 5% mannitol, 5% trehalose, and 0.02% Tween™-80
• Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible

Shipping Condition: Room Temperature. Manufactured by Sino Biological (China).

Specifications

• For Use With (Application): Protein Expression and Isolation, Enzyme and Protein Activity Assay, Protein Assay Control, Reference Standards and Accessories
• Molecular Weight (g/mol): 26kDa
• Quantity: 5 x 50 μg
• Storage Requirements: Store at -20° to -70°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed.
• Structural Form: Truncated/Recombinant
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: Fc region of human immunoglobulin G1
• Common Name: Fc region of human immunoglobulin G1
• Gene Symbol: IgG1-Fc
• Protein Tag: IgG1 Fc Tag
• Expression System: Mammalian
• Protein Family: Growth Factors & Receptors
• Form: Lyophilized
• Protein Subtype: Other Proteins
• Purity or Quality Grade: ≥95% by SDS-PAGE

For Research Use Only. Not for use in diagnostic procedures.