SIGLEC6 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 13454-1-AP-150UL

Product Code. 16811684

Description

SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predomitly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.

Specifications

• Antigen: SIGLEC6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIGLEC6
• Gene Alias: CD327, CD33 antigen like 1, CD33L, CD33L1, CDw327, OB BP1, OBBP1, Obesity binding protein 1, SIGLEC 6, SIGLEC6
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 946
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.13 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O43699
• Gene Symbols: SIGLEC6
• Immunogen: SIGLEC6 Fusion Protein Ag4281
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG